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Comment
. 2013 Mar;62(3):706-8.
doi: 10.2337/db12-1418.

TCF7L2 and glucose metabolism: time to look beyond the pancreas

Marcelo A Nobrega  1
Affiliations
Comment

TCF7L2 and glucose metabolism: time to look beyond the pancreas

Marcelo A Nobrega. Diabetes. 2013 Mar.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Tissue-specific metabolic actions of TCF7L2. While significant attention has been directed toward TCF7L2’s effects in pancreatic β-cells, this transcription factor is highly expressed in multiple organs and tissues involved in glucose metabolism. The physiological roles of TCF7L2 in these tissues remain incompletely defined and may uncover additional mechanisms by which genetic variants in the TCF7L2 locus are associated with increased risk to T2D. In this issue of Diabetes, Shao et al. (13) describe how TCF7L2 expression in the brain intersects with aspects of the central regulation of glucose metabolism. GCG, glucagon gene.
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References

    1. Krützfeldt J, Stoffel M. Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice. Diabetologia 2010;53:123–127 - PubMed
    1. Lyssenko V, Lupi R, Marchetti P, et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007;117:2155–2163 - PMC - PubMed
    1. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 2008;57:645–653 - PubMed
    1. Murtaugh LC, Law AC, Dor Y, Melton DA. Beta-catenin is essential for pancreatic acinar but not islet development. Development 2005;132:4663–4674 - PubMed
    1. da Silva Xavier G, Mondragon A, Sun G, et al. Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia 2012;55:2667–2676 - PMC - PubMed

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