Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec;10(3):185-9.
doi: 10.9758/cpn.2012.10.3.185. Epub 2012 Dec 20.

Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects

Shin-Ya Watanabe  1 , Jun-Ichi Iga, Shusuke Numata, Masahito Nakataki, Toshihito Tanahashi, Mitsuo Itakura, Tetsuro Ohmori
Affiliations

Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects

Shin-Ya Watanabe et al. Clin Psychopharmacol Neurosci. 2012 Dec.

Abstract

Objective: Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects.

Methods: Three hundred fifty one patients with schizophrenia and 342 age- and sex-matched healthy subjects participated in the study. Information on BMI and antipsychotic medication was also collected from patients and healthy subjects. Genotype of the FTO SNP rs9939609 was determined by TaqMan SNP Genotyping Assays.

Results: There was no significant difference in BMI between patients and healthy subjects. No significant difference in BMI was observed among any medications. We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects. There was a significant difference in BMI between healthy subjects with risk (AA or TA) genotypes and those with TT genotype. We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects.

Conclusion: Our study suggested that FTO rs9939609 polymorphism might have some impacts on the BMI in healthy subjects, but might not have same impacts on the BMI of patients with schizophrenia.

Keywords: Antipsychotics agents; Body mass index; Fat-mass and obesity-associated; Gene association studies; Schizophrenia.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Most patients (62.4%) were treated with poly-pharmacy. No significant difference in body mass index (BMI) was observed among any medications. Poly, polypharmacy; RIS, risperidone; OLZ, olanzapine; PER, perospirone; QUE, quetiapine; HPD, haloperidol.
Fig. 2
Fig. 2
The carriers of AA/AT genotypes had significant higher body mass index (BMI) than those of TT genotype in healthy subjects (p=0.017). *p<0.05. SD, standard deviation.
Fig. 3
Fig. 3
Significant correlation between the number of A allele of rs9939609 SNP and body mass index (BMI) in healthy subjects (p=0.002, R2=0.028). SD, standard deviation.
Fig. 4
Fig. 4
There was no significant difference in body mass index (BMI) between the carriers of TT genotype and those of AA/AT genotype in schizophrenia (p=0.851). SD, standard deviation.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Casey DE, Haupt DW, Newcomer JW, Henderson DC, Sernyak MJ, Davidson M, et al. Antipsychotic-induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophrenia. J Clin Psychiatry. 2004;65(Suppl 7):4–18. - PubMed
    1. De Luca V, Mueller DJ, de Bartolomeis A, Kennedy JL. Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis. Int J Neuropsychopharmacol. 2007;10:697–704. - PubMed
    1. Gunes A, Melkersson KI, Scordo MG, Dahl ML. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. J Clin Psychopharmacol. 2009;29:65–68. - PubMed
    1. Sicard MN, Zai CC, Tiwari AK, Souza RP, Meltzer HY, Lieberman JA, et al. Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis. Pharmacogenomics. 2010;11:1561–1571. - PubMed
    1. Hong CJ, Lin CH, Yu YW, Chang SC, Wang SY, Tsai SJ. Genetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment. Psychiatr Genet. 2002;12:169–171. - PubMed