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. 2013 Apr;13(4):839-850.
doi: 10.1111/ajt.12174. Epub 2013 Feb 22.

A thematic analysis of quality of life in lung transplant: the existing evidence and implications for future directions

J P Singer  1   2 , J Chen  2 , P D Blanc  1   2   3 , L E Leard  1 , J Kukreja  4 , H Chen  5
Affiliations

A thematic analysis of quality of life in lung transplant: the existing evidence and implications for future directions

J P Singer et al. Am J Transplant. 2013 Apr.

Abstract

Health-related quality of life (HRQL) has been assessed in various lung transplantation (LT) investigations but never analyzed systematically across multiple studies. We addressed this knowledge gap through a systematic literature review. We searched the PubMed, CINAHL and PsychInfo databases for publications from January 1, 1983 to December 31, 2011. We performed a thematic analysis of published studies of HRQL in LT. Using a comparative, consensus-based approach, we identified themes that consistently emerged from the data, classifying each study according to primary and secondary thematic categories as well as by study design. Of 749 publications initially identified, 73 remained after exclusions. Seven core themes emerged: (1) Determinants of HRQL; (2) Psychosocial factors in HRQL; (3) Pre- and posttransplant HRQL comparisons; (4) Long-term longitudinal HRQL studies; (5) HRQL effects of therapies and interventions; (6) HRQL instrument validation and methodology; (7) HRQL prediction of clinical outcomes. Overall, LT significantly and substantially improves HRQL, predominantly in domains related to physical health and functioning. The existing literature demonstrates substantial heterogeneity in methodology and approach; relatively few studies assessed HRQL longitudinally within the same persons. Opportunity for future study lies in validating existing and potential novel HRQL instruments and further elucidating the determinants of HRQL through longitudinal multidimensional investigation.

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Figures

Figure 1
Figure 1
Systematic review and thematic analysis process.
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References

    1. Busschbach JJ, Horikx PE, van den Bosch JM, Brutel de la Riviere A, de Charro FT. Measuring the quality of life before and after bilateral lung transplantation in patients with cystic fibrosis. Chest. 1994;105:911–7. - PubMed
    1. Eskander A, Waddell TK, Faughnan ME, Chowdhury N, Singer LG. BODE index and quality of life in advanced chronic obstructive pulmonary disease before and after lung transplantation. J Heart Lung Transplant. 2011 - PubMed
    1. Limbos MM, Chan CK, Kesten S. Quality of life in female lung transplant candidates and recipients. Chest. 1997;112:1165–74. - PubMed
    1. Ramsey SD, Patrick DL, Lewis S, Albert RK, Raghu G. Improvement in quality of life after lung transplantation: a preliminary study. The University of Washington Medical Center Lung Transplant Study Group. J Heart Lung Transplant. 1995;14:870–7. - PubMed
    1. TenVergert EM, Vermeulen KM, Geertsma A, et al. Quality of life before and after lung transplantation in patients with emphysema versus other indications. Psychol Rep. 2001;89:707–17. - PubMed

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