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. 2013 Oct;10(5):612-5.
doi: 10.1111/iwj.12052. Epub 2013 Feb 24.

Application of platelet-rich gel to enhance healing of transmetatarsal amputations in diabetic dysvascular patients

Raffaele Serra  1 , Gianluca Buffone, Andrea Dominijanni, Vincenzo Molinari, Rossella Montemurro, Stefano de Franciscis
Affiliations

Application of platelet-rich gel to enhance healing of transmetatarsal amputations in diabetic dysvascular patients

Raffaele Serra et al. Int Wound J. 2013 Oct.

Abstract

Transmetatarsal amputation (TMA) represents an effective surgical procedure used to treat several clinical conditions such as forefoot infection, gangrene and chronic ulceration in diabetic patients. TMA permits walking without the need for prosthesis, but nevertheless is burdened with a high complications rate. The aim of this study was to evaluate the possibility to use platelet gel (PG) as an adjuvant therapy when performing TMA procedure in diabetic patients. In a 6-year period, 26 diabetic patients had undergone TMA procedure followed by autologous PG applications (group A) and 32 patients had undergone TMA as sole procedure (group B). After TMA procedure, the treatment is based on outpatient management and consists of a weekly platelet-rich plasma gel application on the surgical wound for 1 month in group A and on clinical evaluation only for group B. For group A, healing rate was of 96.15% and one patient (3.84%) presented wound dehiscence, and no postoperative wound infections occurred. For group B, healing rate was of 59.37%; severe infection of the stump prompted to the proximal amputations in 40.62% of patients during the follow-up period. PG application may be an effective adjuvant treatment to improve wound healing in diabetic dysvascular patients.

Keywords: Diabetic foot; Diabetic patients; Platelet gel; Transmetatarsal amputation; Wound healing.

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Figures

Figure 1
Figure 1
Image showing the incisional approach.
Figure 2
Figure 2
Imaging showing the incisional approach around the forefoot.
Figure 3
Figure 3
Application of platelet gel on plantar flap.
Figure 4
Figure 4
Example of final result after 1 week from procedure.
See this image and copyright information in PMC

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