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Meta-Analysis
. 2013 Jul-Aug;27(4):357-64.
doi: 10.1016/j.jdiacomp.2013.01.004. Epub 2013 Feb 20.

Diabetes mellitus and incidence and mortality of kidney cancer: a meta-analysis

Cuiping Bao  1 , Xilin Yang, Weili Xu, Hongbin Luo, Zhongliang Xu, Cheng Su, Xiuying Qi
Affiliations
Meta-Analysis

Diabetes mellitus and incidence and mortality of kidney cancer: a meta-analysis

Cuiping Bao et al. J Diabetes Complications. 2013 Jul-Aug.

Abstract

Background: Diabetes is associated with increased risk of a spectrum of cancers, but there are few meta-analyses on the association between diabetes and kidney cancer. We performed a meta-analysis of case-control studies and cohort studies to address the incidence and mortality of kidney cancer in diabetes.

Methods: Studies were identified by searching PubMed database and manual assessment of the cited references in the retrieved articles. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a random-effect model. Study quality was assessed using the Newcastle-Ottawa scale.

Results: A total of 24 studies were included. We found that diabetes was significantly associated with increased risk of kidney cancer (RR=1.40, 95% CI=1.16 to 1.69), and the results were consistent between case-control and cohort studies. A slightly stronger positive relation was observed in women (RR=1.47, 95% CI=1.18 to 1.83) than in men (RR=1.28, 95% CI=1.10 to 1.48). Additional analyses indicated that the increased risk of kidney cancer was independent of alcohol consumption, body mass index (BMI)/obesity and smoking. However, there was no association between diabetes and mortality of kidney cancer (RR=1.12, 95% CI=0.99 to 1.20), without heterogeneity (P=0.419, I(2)=1.8%).

Conclusions: Diabetes mellitus may increase the risk of kidney cancer in both women and men.

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