Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2013 Feb;53(2):234-9.
doi: 10.1177/0091270012445793. Epub 2013 Jan 24.

Population pharmacokinetic modeling of sertraline treatment in patients with Alzheimer disease: the DIADS-2 study

Claire H Li  1 , Bruce G Pollock, Constantine G Lyketsos, Vijay Vaidya, Lea T Drye, Margaret Kirshner, Denise Sorisio, Robert R Bies; DIADS-2 Research Group
Collaborators, Affiliations
Randomized Controlled Trial

Population pharmacokinetic modeling of sertraline treatment in patients with Alzheimer disease: the DIADS-2 study

Claire H Li et al. J Clin Pharmacol. 2013 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

Bruce G. Pollock, receives research support from the National Institute of Health, Canadian Institutes of Health Research, American Psychiatric Association and the Foundation of the Centre for Addiction and Mental Health. Within the past two years he has been a faculty member of the Lundbeck International Neuroscience Foundation (LINF) (last meeting was April 2010).

Constantine Lyketsos was involved in another trial for which Pfizer donated a different drug; he also was involved in research sponsored by Forest to study escitalopram and citalopram and Pfizer to study sertraline and donepezil; Dr. Lyketsos served as a consultant for Organon, Eisai, GSK, Lilly, Wyeth, and Pfizer.

Robert R. Bies is funded through the Indiana Clinical Translational Sciences Institute from a gift of Eli Lilly and Company. Dr. Bies is also a scientific advisory board member for the Metrum Institute.

Claire H. Li, Vijay Vaidya, Lea T. Drye, Margaret Kirshner, and Denise Sorisio report no conflicts of interest.

References

    1. Steinberg M, Shao H, Zandi P, et al. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry. 2008;23(2):170–177. - PMC - PubMed
    1. Martin BK, Frangakis CE, Rosenberg PB, et al. Design of Depression in Alzheimer’s Disease Study-2. AmJ Geriatr Psychiatry. 2006;14(11):920–930. - PubMed
    1. Hiemke C, Härtter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology & Therapeutics. 2000;85:11–28. - PubMed
    1. Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet. 2009;373(9665):746–58. - PubMed
    1. Owen MJ, Morgan WN, Plott SJ, et al. Neurotransmitter receptor and transporter binging profile of antidepressants and their metabolites. JPET. 1997;283:1305–1322. - PubMed

Publication types