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Meta-Analysis
. 2013 Mar;200(3):624-9.
doi: 10.2214/AJR.12.8679.

ADC values and prognosis of malignant astrocytomas: does lower ADC predict a worse prognosis independent of grade of tumor?--a meta-analysis

Maria Zulfiqar  1 , David M Yousem, Hong Lai
Affiliations
Meta-Analysis

ADC values and prognosis of malignant astrocytomas: does lower ADC predict a worse prognosis independent of grade of tumor?--a meta-analysis

Maria Zulfiqar et al. AJR Am J Roentgenol. 2013 Mar.

Abstract

Objective: The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade.

Materials and methods: Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed.

Results: The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and < 0.0001, respectively) were worse below a specific ADC value, independent of grade.

Conclusion: Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.

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