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. 2013 Feb;9(2):e1003143.
doi: 10.1371/journal.ppat.1003143. Epub 2013 Feb 21.

Bacterial survival amidst an immune onslaught: the contribution of the Staphylococcus aureus leukotoxins

Francis Alonzo 3rd  1 , Victor J Torres
Affiliations

Bacterial survival amidst an immune onslaught: the contribution of the Staphylococcus aureus leukotoxins

Francis Alonzo 3rd et al. PLoS Pathog. 2013 Feb.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Overview of S. aureus leukotoxin action on host immune cells.
The above schematic illustrates our current understanding of leukotoxin targeting and the functional consequences of toxin activity on specific immune cell types. Upon encountering host immune cells, S. aureus elaborates numerous molecules that facilitate escape from bacterial killing. The bi-component leukotoxins (LukAB, red; HlgCB, green; PVL, gray; HlgAB, purple; LukED, orange) are one class of lytic molecules that directly target and kill immune cells. The cells types currently known to be targets of each leukotoxin are shown. While the leukotoxins possess potent lytic capacity on their cellular targets, evidence also suggests a sublytic influence of PVL. The downstream effects of sublytic toxin activity, including inflammasome activation and enhanced bactericidal activity are shown.
See this image and copyright information in PMC

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