Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Apr;61(4):757-61.
doi: 10.1161/HYPERTENSIONAHA.111.00770. Epub 2013 Feb 25.

Investing in high blood pressure research: a national institutes of health perspective

Zorina S Galis  1 , Terry Thrasher, Diane M Reid, Dennis V Stanley, Young S Oh
Affiliations
Review

Investing in high blood pressure research: a national institutes of health perspective

Zorina S Galis et al. Hypertension. 2013 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Hypertension research is sponsored by several National Institutes of Health (NIH) Institutes and Centers (ICs). In fiscal year 2011, a total of $240 million was invested in 677 hypertension- related awards, with the National Heart, Lung, and Blood Institute (NHLBI) being the major sponsor both in terms of number of awards (A) and amount of funding (B). NIDDK indicates National Institute of Diabetes and Digestive and Kidney Diseases.
Figure 2.
Figure 2.
The National Institutes of Health (NIH; A, B) and National Heart, Lung, and Blood Institute (NHLBI; C, D) sponsor various types of research efforts related to hypertension. We assigned each of the hypertension-related awards funded in fiscal year (FY) 2011 to 1 of 3 categories: basic/translational research, clinical trial, or training grant. A, The largest number of NIH supported awards were basic/translational research projects (535 awards), followed by clinical trials (56 awards), and training grants (86 awards). B, By amount of funding, NIH spent 81% ($194 million) in basic/translational research projects, 15% ($35 million) in clinical trials, and 4% ($11 million) in training grants. Numbers were rounded to the million. C, Of 408 awards NHLBI funded in FY2011, NHLBI also supported mainly basic/translational research (332 awards), followed by clinical trials (30 awards), and training grants (46 awards). B, Calculating by amount of funding, a similar ranking was found, with 86% funds invested in basic/translational research projects, 10% in clinical trials, and 4% in training grants. Numbers were rounded to the million.
Figure 3.
Figure 3.
National Heart, Lung, and Blood Institute (NHLBI) used a variety of funding mechanisms to sponsor basic and translational (B/T) hypertension-related research in fiscal year (FY) 2011, which included traditional research awards series (R01, P01, R21) and others (ie, R37, P50, U01, etc). When we analyzed the distribution by (A) number or by (B) US dollars invested in FY2011 among various funding mechanisms, the individual R01s predominated (62% from total number or 67% of investments), followed by P01 (28% from total number or 24% of investments). Each subproject and core of P01s was counted as an individual award.
Figure 4.
Figure 4.
Analysis of Vascular Biology and Hypertension Branch (VBHB)-sponsored hypertension research by (A) major target organ studied and (B) major experimental model used. A, Each award was assigned based on its main focus to 1 of the 3 categories: vasculature, kidney, or brain. Funding was found to be fairly equally distributed between these 3 categories. A small percentage of awards were assigned to the closest fit category. B, Each award was classified based on the main type of experimental model used to induce hypertension. Angiotensin (Ang) II-induced models received almost half of the total funding. Other used models included genetic models and those where hypertension was induced by diet, chronic intermittent hypoxia (CIH), endothelin, DOCA (deoxycorticosterone acetate) salt and high sodium (Na), or aging.
See this image and copyright information in PMC

References

    1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206–1252. - PubMed
    1. Roger VL, Go AS, Lloyd-Jones DM, et al.; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation. 2012;125:e2–e220. - PMC - PubMed
    1. Sug Yoon S, Burt V. Hypertension among adults in the United States, 2009–2010, 2012; http://www.cdc.gov/nchs/data/databriefs/db107.pdf. - PubMed
    1. The National Institutes of Health (NIH) home page. www.nih.gov.
    1. Glasser SP, Judd S, Basile J, Lackland D, Halanych J, Cushman M, Prineas R, Howard V, Howard G. Prehypertension, racial prevalence and its association with risk factors: Analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Am J Hypertens. 2011;24:194–199. - PMC - PubMed