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Comment
. 2013 Feb 20;77(4):597-8.
doi: 10.1016/j.neuron.2013.02.009.

RANTing about C9orf72

Tammaryn Lashley  1 , John Hardy, Adrian M Isaacs
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RANTing about C9orf72

Tammaryn Lashley et al. Neuron. .
Free article

Abstract

A noncoding repeat expansion in the C9orf72 gene is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. In this issue of Neuron, Ash et al. (2013) show that despite being noncoding the repeats are translated, leading to widespread neuronal aggregates of the translated proteins.

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