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Case Reports
. 2013 May;57(5):2388-90.
doi: 10.1128/AAC.02399-12. Epub 2013 Feb 25.

Effectiveness of a double-carbapenem regimen for infections in humans due to carbapenemase-producing pandrug-resistant Klebsiella pneumoniae

Helen Giamarellou  1 , Lambrini Galani, Fotini Baziaka, Ilias Karaiskos
Affiliations
Case Reports

Effectiveness of a double-carbapenem regimen for infections in humans due to carbapenemase-producing pandrug-resistant Klebsiella pneumoniae

Helen Giamarellou et al. Antimicrob Agents Chemother. 2013 May.

Abstract

Ertapenem plus doripenem or meropenem were given in three patients suffering from pandrug-resistant, KPC-2-positive Klebsiella pneumoniae bacteremia (2 patients) and urinary tract infection (1 patient), respectively. All responded successfully, without relapse at follow-up. The results obtained should probably be attributed to ertapenem's increased affinity for the carbapenemases hindering doripenem/meropenem degradation in the environment of the microorganism.

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