Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;2(1):27-33.

High-sensitivity C-reactive protein (hs-CRP) and tumor necrotizing factor-alpha (TNF-alpha) after on- and off- pump coronary artery bypass grafting

H Javadzadegan  1 , N Nezami, K Ghobadi, A Sadighi, A A Abolfathi, N D Nader
Affiliations

High-sensitivity C-reactive protein (hs-CRP) and tumor necrotizing factor-alpha (TNF-alpha) after on- and off- pump coronary artery bypass grafting

H Javadzadegan et al. HSR Proc Intensive Care Cardiovasc Anesth. 2010.

Abstract

Introduction: Coronary artery bypass grafting (CABG) is one of the most frequently performed operations around the world. The aim of this study is to evaluate high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-alpha) differences between on-pump and off-pump coronary surgery.

Methods: In this prospective study, 90 patients with coronary artery disease referred for CABG were enrolled from July 2006-November 2007. Levels of hs-CRP and TNF-alpha were measured by ELISA using commercial kits

Results: hs-CRP levels significantly (p<0.001) increase after CABG. But no difference between off-pump and on-pump groups was noted for hs-CRP and TNF-alpha levels (p=0.4, p=0.8).

Conclusions: There was no difference in high-sensitivity C-reactive protein (hs-CRP) and TNF-alpha between on-pump and off-pump CABG surgery.

Keywords: C-reactive protein (CRP); cardiopulmonary bypass; coronary artery bypass grafting; off-pump; on-pump; tumor necrotizing factor-alpha (TNF-alpha).

PubMed Disclaimer

Figures

Table 1
Table 1
Demographics and surgical characteristics.
Table 2
Table 2
Medication history of the participants according to their surgical group.
Table 3
Table 3
Comparison of biochemical parameters between On-pump and off-pump.
Table 4
Table 4
Comparison of hsCRP and TNF-alpha levels between study groups.
See this image and copyright information in PMC

References

    1. Howson CP, Fineberg HV, Bloom BR. The pursuit of global health: the relevance of engagement for developed countries. Lancet. 1998;35:586–590. - PubMed
    1. Yacoub M. Off-pump coronary bypass surgery: in search of an identity. Circulation. 2001;104:1743–1745. - PubMed
    1. Franke A, Lante W, Fackeldey V. et al. Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know? Eur J Cardiothorac. 2005;28:569–575. - PubMed
    1. Levy JH, Tanaka KA. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg. 2003;75:715–720. - PubMed
    1. Cleveland JC jr, Shroyer AL, Chen AY. et al. Off-pump coronary artery bypass grafting decreases risk-adjusted mortality and morbidity. Ann Thorac Surg. 2001;72:1282–1288. - PubMed

LinkOut - more resources