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. 2013 Feb;108(1):23-9.
doi: 10.1590/s0074-02762013000100004.

Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil

Paulo Victor Pereira Baio  1 , Higor Franceschi Mota, Andréa D'avila Freitas, Débora Leandro Rama Gomes, Juliana Nunes Ramos, Lincoln Oliveira Sant'Anna, Mônica Cristina Souza, Thereza Cristina Ferreira Camello, Raphael Hirata Junior, Verônica Viana Vieira, Ana Luíza Mattos-Guaraldi
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Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil

Paulo Victor Pereira Baio et al. Mem Inst Oswaldo Cruz. 2013 Feb.

Abstract

Corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. Here, we document a nosocomial outbreak caused by multidrug-resistant (MDR) C. striatum in Rio de Janeiro, Brazil. C. striatum identification was confirmed by 16S rRNA and rpoB gene sequencing. Fifteen C. striatum strains were isolated from adults (half of whom were 50 years of age and older). C. striatum was mostly isolated in pure culture from tracheal aspirates of patients undergoing endotracheal intubation procedures. The analysis by pulsed-field gel electrophoresis (PFGE) indicated the presence of four PFGE profiles, including two related clones of MDR strains (PFGE I and II). The data demonstrated the predominance of PFGE type I, comprising 11 MDR isolates that were mostly isolated from intensive care units and surgical wards. A potential causal link between death and MDR C. striatum (PFGE types I and II) infection was observed in five cases.

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Figures

Fig. 1
Fig. 1. epidemic curve for Corynebacterium striatum over time.
Fig. 2
Fig. 2. phylogenetic tree based on neighbour-joining method using 16S rRNA gene sequences. Distance estimations were calculated by using the Kimura two-parameter model. Bootstrap percentages after 1,000 simulations are shown. The Actinomyces bovis (T) X81061 sequence was used as outgroup.
Fig. 3
Fig. 3. pulsed-field gel electrophoresis (PFGE) profiles of Brazilian Corynebacterium striatum isolates. Lane 1: λ DNA ladder PFGE marker; 2-5, 7: profile I (isolates 1958, 1959, 1987, 1974 and 2539, respectively); 6: profile II (isolate 2369); 8, 9: profile III (isolate 1961); 10: profile IV (isolate 1954).
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References

    1. Adderson EE, Boudreaux JW, Hayden RT. Infections caused by coryneform bacteria in pediatric oncology patients. Pediatr Infect Dis J. 2008;27:136–141. - PubMed
    1. Almuzara MN, De Mier C, Rodríguez CR, Famiglietti AM, Vay CA. Evaluation of API Coryne System version 2.0 for diphtheroid gram-positive rods identification with clinical relevance. Rev Argent Microbiol. 2006;38:197–201. - PubMed
    1. Boltin D, Katzir M, Bugoslavsky V, Yalashvili I, Brosh-Nissimov T, Fried M, Elkayam O. Corynebacterium striatum - a classic pathogen eluding diagnosis. Eur J Intern Med. 2009;20:49–52. - PubMed
    1. Brandenburg AH, van Belkum A, van Pelt C, Bruining HA, Mouton JW, Verbrugh HA. Patient-to-patient spread of a single strain of Corynebacterium striatum causing infections in a surgical intensive care unit. J Clin Microbiol. 1996;34:2089–2094. - PMC - PubMed
    1. Camello TCF, Mattos-Guaraldi AL, Formiga LCD, Marques EA. Nondiphtherial Corynebacterium species isolated from clinical specimens of patients in a University hospital, Rio de Janeiro, Brazil. Braz J Microbiol. 2003;34:39–44.

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