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. 2010;2(2):111-7.

Fenoldopam to prevent renal replacement therapy after cardiac surgery. Design of the FENO-HSR study

G Landoni  1 , T Bove, D Pasero, M Comis, S Orando, F Pinelli, F Guarracino, A Corcione, N Galdieri, M Zucchetti, E Maglioni, B Biagioli, G Pala, M Frontini, F Caramelli, B Persi, M Renzini, F Paoletti, L Lorini, A Morelli, G Alvaro, R Bianco, D Pittarello, A Manzato, G Pedersini, A Mizzi, N Lojacono, P Leoncini, T Iovino, C Cariello, R Baldassarri, A M Camata, G Padua, G Frascaroli, S Leonardi, E Bignami, A Zangrillo
Affiliations

Fenoldopam to prevent renal replacement therapy after cardiac surgery. Design of the FENO-HSR study

G Landoni et al. HSR Proc Intensive Care Cardiovasc Anesth. 2010.

Abstract

Introduction: Acute kidney injury requiring renal replacement therapy is a serious complication following cardiac surgery associated with poor clinical outcomes. Until now no drug showed nephroprotective effects. Fenoldopam is a dopamine-1 receptor agonist which seems to be effective in improving postoperative renal function. The aim of this paper is to describe the design of the FENO-HSR study, planned to assess the effect of a continuous infusion of fenoldopam in reducing the need for renal replacement therapy in patients with acute kidney injury after cardiac surgery.

Methods: We're performing a double blind, placebo-controlled multicentre randomized trial in over 20 Italian hospitals. Patients who develop acute renal failure defined as R of RIFLE score following cardiac surgery are randomized to receive a 96-hours continuous infusion of either fenoldopam (0.025-0.3 µg/kg/min) or placebo.

Results: The primary endpoint will be the rate of renal replacement therapy. Secondary endpoints will be: mortality, time on mechanical ventilation, length of intensive care unit and hospital stay, peak serum creatinine and the rate of acute renal failure (following the RIFLE score).

Conclusions: This trial is planned to assess if fenoldopam could improve relevant outcomes in patients undergoing cardiac surgery who develop acute renal dysfunction. Results of this double-blind randomized trial could provide important insights to improve the management strategy of patients at high risk for postoperative acute kidney injury.

Keywords: acute renal failure; anesthesia; cardiac surgery; cardiac surgical procedures; fenoldopam; renal replacement therapy.

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Figures

Table 1
Table 1
RIFLE score for acute renal failure.
Table 2
Table 2
A clinical score to predict acute renal failure after cardiac surgery according to Tankar et al. (15)
Table 3
Table 3
The Continuous Improvement in Cardiac Surgery Study score (CICSS) by Chertow et al. (16).
Table 4
Table 4
The Simplified model to predict postoperative dialysis by Metha el al. (18).
Table 5
Table 5
A simplified predictive index for renal replacement therapy after cardiac surgery suggested by Wijeysundera et al. (18).
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References

    1. Landoni G, Roberti A, Boroli F. et al. Mitral valve surgery and acute renal failure. Eur J Anaesthesiol. 2007;24:100–101. - PubMed
    1. Landoni G, Bove T, Crivellari M. et al. Acute renal failure after isolated CABG surgery: six years of experience. Minerva Anestesiol. 2007;73:559–565. - PubMed
    1. Bove T, Calabrò MG, Landoni G. et al. The incidence and risk of acute renal failure after cardiac surgery. J Cardiothorac Vasc Anesth. 2004;18:442–445. - PubMed
    1. Landoni G, Zangrillo A, Franco A. et al. Long-term outcome of patients who require renal replacement therapy after cardiac surgery. Eur J Anaesthesiol. 2006;23:17–22. - PubMed
    1. Schetz M, Bove T, Morelli A. et al. Prevention of cardiac surgery-associated acute kidney injury. Int J Artif Organs. 2008;31:179–189. - PubMed

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