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. 2013 Feb 26;14(3):4655-69.
doi: 10.3390/ijms14034655.

Long non-coding RNA in cancer

Nina Hauptman  1 , Damjan Glavač
Affiliations

Long non-coding RNA in cancer

Nina Hauptman et al. Int J Mol Sci. .

Abstract

Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers.

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Figures

Figure 1
Figure 1
Categories of long non-coding RNA (lncRNA).
See this image and copyright information in PMC

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