Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2013 May;26(5):643-56.
doi: 10.1093/ajh/hps099. Epub 2013 Feb 26.

Common genetic variants in the endothelial system predict blood pressure response to sodium intake: the GenSalt study

Maria Daniela Defagó  1 , Dongfeng Gu, James E Hixson, Lawrence C Shimmin, Treva K Rice, Charles C Gu, Cashell E Jaquish, De-Pei Liu, Jiang He, Tanika N Kelly
Affiliations
Comparative Study

Common genetic variants in the endothelial system predict blood pressure response to sodium intake: the GenSalt study

Maria Daniela Defagó et al. Am J Hypertens. 2013 May.

Abstract

BACKGROUND We examined the association between 14 endothelial system genes and salt-sensitivity of blood pressure (BP). METHODS After a 3-day baseline examination, during which time the usual diet was consumed, 1,906 Chinese participants received a 7-day low-sodium diet (51.3 mmol of sodium/day) followed by a 7-day high-sodium diet (307.8 mmol of sodium/day). BP measurements were obtained at baseline and at the end of each intervention using a random-zero sphygmomanometer. RESULTS The DDAH1 rs11161637 variant was associated with reduced BP salt sensitivity, conferring attenuated systolic BP (SBP) and mean arterial pressure (MAP) decreases from baseline to the low-sodium intervention (both P = 2×10(-4)). Examination of genotype-sex interactions revealed that this relation was driven by the strong associations observed in men (P for interactions = 1.10×10(-4) and 0.008, respectively). When switching from the low- to high-sodium intervention, increases in diastolic BP (DBP) and MAP were attenuated by the COL18A1 rs2838944 minor A allele (P = 1.41×10(-4) and 1.55×10(-4), respectively). Conversely, the VWF rs2239153 C variant was associated with increased salt sensitivity, conferring larger DBP and MAP reductions during low-sodium intervention (P = 1.22×10(-4) and 4.44×10(-5), respectively). Ten variants from 3 independent SELE loci displayed significant genotype-sex interactions on DBP and MAP responses to low-sodium (P for interaction = 1.56×10(-3) to 1.00×10(-4)). Among men, minor alleles of 4 correlated markers attenuated BP responses to low-sodium intake, whereas minor alleles of another 4 correlated markers increased BP responses. No associations were observed in women for these variants. Further, qualitative interactions were shown for 2 correlated SELE markers. CONCLUSIONS These data support a role for the endothelial system genes in salt sensitivity.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Log P values for the association between 292 single nucleotide polymorphisms in 14 candidate genes and systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) responses to low- (a) and high-sodium (b) interventions. Labeled single nucleotide polymporphisms had Q < 0.05. SNPs.
Figure 2.
Figure 2.
Log P values for the genotype–sex interactions of 292 single nucleotide polymorphisms in 14 candidate genes and systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) responses to low- (a) and high-sodium (b) interventions. Labeled SNPs had Q < 0.05.
See this image and copyright information in PMC

References

    1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217–223 - PubMed
    1. Danaei G, Finucane MM, Lin JK, Singh GM, Paciorek CJ, Cowan MJ, Farzadfar F, Stevens GA, Lim SS, Riley LM, Ezzati M. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Pressure) National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants. Lancet 2011; 377: 568–577 - PubMed
    1. Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RTH, Nabika T, Gu D, Chang L, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee JY, Seielstad M, Isono M, Hixson JE, Chen YT, Miki T, Zhang X, Sugiyama T, Jeon JP, Liu JJ, Takayanagi R, Kim SS, Aung T, Sung YJ, Zhou X, Wong TY, Han BG, Kobayashi S, Ogihara T, Zhu D, Iwai N, Wu JY, Teo YY, Tai ES, Cho YS, He J. Meta-analysis identifies five novel loci associated with blood pressure in East Asians. Nat Genet 2011; 43: 531–538 - PMC - PubMed
    1. Whelton PK, He J, Appel LJ, Cutler JA, Havas S, Kotchen TA, Roccella EJ, Stout R, Vallbona C, Winston MC, Karimbakas J. National High Blood Pressure Education Program Coordinating Committee Primary prevention of hypertension: clinical and public health advisory from the National High Blood Pressure Education Program. JAMA 2002; 288: 1882–1888 - PubMed
    1. He J, Whelton PK. Salt intake, hypertension and risk of cardiovascular disease: an important public health challenge. Int J Epidemiol 2002; 31: 327–331 - PubMed

Publication types

MeSH terms