Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Mar;12(3):245-54.
doi: 10.1158/1535-7163.MCT-12-0712. Epub 2013 Feb 26.

FOX(M1) news--it is cancer

Marianna Halasi  1 , Andrei L Gartel
Affiliations
Review

FOX(M1) news--it is cancer

Marianna Halasi et al. Mol Cancer Ther. 2013 Mar.

Abstract

FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in quiescent or differentiated cells, but its level is highly elevated in proliferating and malignant cells. Overexpression of FOXM1 has been reported in more than 20 types of human cancer. In recent years, FOXM1 has been implicated in diverse cellular processes and also a growing body of experimental data has underlined the relevance of FOXM1 in tumorigenesis. Although FOXM1 is under the control of three major tumor suppressors (RB, p53, and p19(ARF)), it is still active in the majority of human cancers. The oncogenic potential of FOXM1 is mainly based on its ability to transcriptionally activate genes that are involved in different facets of cancer development. In this review, the contribution of FOXM1 to each of the hallmarks of cancer will be summarized and discussed.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. FOXM1 is involved in all hallmarks of cancer
The schematic depicts the contribution of FOXM1 to the hallmarks of cancer. Negative (in italics and underlined) and positive (in bold) downstream targets or upstream regulators of FOXM1 are shown.
See this image and copyright information in PMC

References

    1. Laoukili J, Stahl M, Medema RH. FoxM1: At the crossroads of ageing and cancer. Biochimica et biophysica acta. 2007;1775:92–102. - PubMed
    1. Kalin TV, Ustiyan V, Kalinichenko VV. Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models. Cell cycle. 2011;10:396–405. - PMC - PubMed
    1. Chen YJ, Dominguez-Brauer C, Wang Z, Asara JM, Costa RH, Tyner AL, et al. A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. The Journal of biological chemistry. 2009;284:30695–30707. - PMC - PubMed
    1. Anders L, Ke N, Hydbring P, Choi YJ, Widlund HR, Chick JM, et al. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer cell. 2011;20:620–634. - PMC - PubMed
    1. Halasi M, Gartel AL. A novel mode of FoxM1 regulation: positive auto-regulatory loop. Cell cycle. 2009;8:1966–1967. - PubMed

Publication types

MeSH terms

Substances