Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb 28;2(1):6.
doi: 10.1186/2047-9158-2-6.

Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer's disease

Zhi-Kun Sun #  1 , Hong-Qi Yang #  1 , Sheng-Di Chen  2
Affiliations

Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer's disease

Zhi-Kun Sun et al. Transl Neurodegener. .

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized clinically by insidious onset of memory and cognition impairment, emergence of psychiatric symptoms and behavioral disorder, and impairment of activities of daily living (ADL). Traditional Chinese medicine (TCM) is practiced in the Chinese health care system for more than 2,000 years. In recent years, scientists have isolated many novel compounds from herbs, some of which improve dementia with fewer side effects than conventional drugs and are regarded as potential anti-AD drugs. In this review, we summarize the latest research progress on TCM showing their possible role of treatment of AD and other demented diseases and possible pharmacological actions.

PubMed Disclaimer

References

    1. Ved HS, Koenig ML, Dave JR, Doctor BP. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport. 1997;8(4):963–968. doi: 10.1097/00001756-199703030-00029. - DOI - PubMed
    1. Wang R, Tang XC. Neuroprotective effects of huperzine A: a natural cholinesterase inhibitor for the treatment of Alzheimer’s disease. Neurosignals. 2005;14(1–2):71–82. - PubMed
    1. Yang L, Ye CY, Huang XT, Tang XC, Zhang HY. Decreased accumulation of subcellular amyloid-beta with improved mitochondrial function mediates the neuroprotective effect of huperzine A. J Alzheimers Dis. 2012;31(1):131–142. - PubMed
    1. Wang Y, Tang XC, Zhang HY. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. J Neurosci Res. 2012;90(2):508–517. doi: 10.1002/jnr.22775. - DOI - PubMed
    1. Ratia M, Gimenez-Llort L, Camps P, Munoz-Torrero D, Perez B, Clos MV, Badia A. Huprine X and huperzine a improve cognition and regulate some neurochemical processes related with Alzheimer’s disease in triple transgenic mice(3xTg-AD) Neurodegener Dis. 2012. Epub ahead of print. - PubMed

LinkOut - more resources