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Review
. 2013 Apr 2;52(14):3822-63.
doi: 10.1002/anie.201201636. Epub 2013 Feb 27.

Industrial applications of the Diels-Alder reaction

Jacques-Alexis Funel  1 , Stefan Abele
Affiliations
Review

Industrial applications of the Diels-Alder reaction

Jacques-Alexis Funel et al. Angew Chem Int Ed Engl. .

Abstract

The Diels-Alder reaction is one of the most popular transformations for organic chemists to generate molecular complexity efficiently. Surprisingly, little is known about its industrial application for the synthesis of pharmacologically active ingredients, agrochemicals, and flavors and fragrances. This Review highlights selected examples, with a focus on large-scale applications (>1 kg) from a process research and development perspective.

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