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Comment
. 2013 Mar;15(3):231-3.
doi: 10.1038/ncb2703.

A one-two punch of miR-126/126* against metastasis

Guangwen Ren  1 , Yibin Kang
Affiliations
Comment

A one-two punch of miR-126/126* against metastasis

Guangwen Ren et al. Nat Cell Biol. 2013 Mar.

Abstract

MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.

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