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Editorial
. 2013 Mar 5;61(9):933-5.
doi: 10.1016/j.jacc.2012.12.016.

Nitroso-redox imbalance affects cardiac structure and function

Vasileios Karantalis, Ivonne Hernandez Schulman, Joshua M Hare
Editorial

Nitroso-redox imbalance affects cardiac structure and function

Vasileios Karantalis et al. J Am Coll Cardiol. .
No abstract available

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Figures

Figure 1
Figure 1. Increased xanthine oxidase activity and nitroso-redox imbalance
The reactive oxygen species generated as a result of purine metabolism contributes to nitroso-redox imbalance. Increased ROS production can lead to peroxynitrite formation and the oxidation of proteins blocking important post-translational nitrosylation modifications. Importantly, decreased NOS activity can activate xanthine oxidase and exacerbate nitroso-redox imbalance. As uric acid is produced in proportion to ROS by XOR, it may serve as a biomarker of increased xanthine oxidase activity and possibly nitroso-redox imbalance.
See this image and copyright information in PMC

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References

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