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Comment
. 2013 Feb 25;24(4):335-6.
doi: 10.1016/j.devcel.2013.02.004.

A bridge to understanding lipid droplet growth

William A Prinz  1
Affiliations
Comment

A bridge to understanding lipid droplet growth

William A Prinz. Dev Cell. .

Abstract

Lipid droplets, storage sites of fatty acids and sterols, expand when excess lipids are converted to triacylglycerols. In this issue of Developmental Cell, Wilfling et al. (2013) show that this expansion relies on relocalization, via membrane bridges, of triacylglycerol-synthesizing enzymes from the ER to a subset of lipid droplets.

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Figures

Figure 1
Figure 1. A Transit Route for Lipid Droplet Expansion
Model of how GPAT4 and other triacylglycerol (TG)-synthesizing enzymes might move from the ER to expanding lipid droplets (eLDs), but not to static lipid droplets (sLDs), after oleate is added to cells to mediate LD growth. Note that this model suggests that ER-LD bridges exist before LD expansion begins.
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References

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