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Comment
. 2013 Feb 25;24(4):342-4.
doi: 10.1016/j.devcel.2013.02.005.

Pioneering barren land: mitotic bookmarking by transcription factors

Alvaro Rada-Iglesias  1
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Pioneering barren land: mitotic bookmarking by transcription factors

Alvaro Rada-Iglesias. Dev Cell. .
Free article

Abstract

Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene expression reestablishment upon mitotic exit.

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