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Comment
. 2013 Feb 28;121(9):1489-91.
doi: 10.1182/blood-2013-01-474221.

ECM: chemoattraction but not adhesion

Anna Huttenlocher  1
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Free article
Comment

ECM: chemoattraction but not adhesion

Anna Huttenlocher. Blood. .
Free article

Abstract

The mechanisms that regulate 3-dimensional (3D) neutrophil chemotaxis are poorly understood. In this issue of Blood, Afonso et al demonstrate that the collagen receptor Discoidin domain receptor 2 (DDR2) promotes neutrophil chemotaxis in 3D by triggering matrix metalloproteinase (MMP) activity and the generation of chemotactic collagen peptides.

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