Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep;10(3):254-62.
doi: 10.2174/157015912803217341.

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Antonio Siniscalchi  1 , Luca Gallelli, Angelo Labate, Giovanni Malferrari, Caterina Palleria, Giovambattista De Sarro
Affiliations

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Antonio Siniscalchi et al. Curr Neuropharmacol. 2012 Sep.

Abstract

Involuntary abnormal movements have been reported after ischaemic and haemorrhagic stroke. Post stroke movement disorders can appear as acute or delayed sequel. At the moment, for many of these disorders the knowledge of pharmacological treatment is still inadequate. Dopaminergic and GABAergic systems may be mainly involved in post-stroke movement disorders. This article provides a review on drugs commonly used in post-stroke movement disorders, given that some post-stroke movement disorders have shown a partial benefit with pharmacological approach.

Keywords: Dopamine; GABA; Post-stroke; hyperkinetic movements disorders; hypokinetic movements disorders; movement disorders; post-stroke recovery..

PubMed Disclaimer

Figures

Fig. (1)
Fig. (1)
Representation of neuronal connections in the basal ganglia. Broken lines represent inhibitory connections, and unbroken lines represent stimulatory connections. SNc: substantial nigra pars compacta; GPi: globus pallidus pars interna; STn: subthalamus nucleus; SNr: substantial nigra pars reticulate; GPe: globus pallidus pars externa. DA: dopamine; Glut: glutamate; GABA: gamma-aminobutyric acid A.
See this image and copyright information in PMC

References

    1. Ghika J, Bogousslavsky J. Stroke Syndromes. In: Bogousslavsky J, Caplan L, editors. Abnormal movements. 2nd. Cambridge: Cambridge University Press; 2001. pp. 162–181.
    1. Handley A, Medcalf P, Hellier K, Dutta D. Movement disorders after stroke. Age Ageing. 2009;38:260–266. - PubMed
    1. Chuang C, Fahn S, Frucht SJ. The natural history and treatment of acquired hemidystonia, report of 33 cases and review of the literature. J. Neurol. Neurosurg. Psychiatry. 2002;72:59–67. - PMC - PubMed
    1. Fahn S. Advances in Neurology; Dystonia 2. In: Fahn S, Marsden CD, Calne DB, editors. Concept and classification of dystonia. New York: Raven Press; 1988. p. 58.
    1. Krystkowiak P, Martinat P, Defebvre L, Pruvo JP, Leys D, Destée A. Dystonia after striatopallidal and thalamic stroke, clinicoradiological correlations and pathophysiological mechanisms. J. Neurol. Neurosurg. Psychiatry. 1998;65:703–708. - PMC - PubMed