Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2013 Feb 28;2013(2):CD009296.
doi: 10.1002/14651858.CD009296.pub2.

Nurse versus physician-led care for the management of asthma

Affiliations
Meta-Analysis

Nurse versus physician-led care for the management of asthma

Maarten C Kuethe et al. Cochrane Database Syst Rev. .

Abstract

Background: Asthma is the most common chronic disease in childhood and prevalence is also high in adulthood, thereby placing a considerable burden on healthcare resources. Therefore, effective asthma management is important to reduce morbidity and to optimise utilisation of healthcare facilities.

Objectives: To review the effectiveness of nurse-led asthma care provided by a specialised asthma nurse, a nurse practitioner, a physician assistant or an otherwise specifically trained nursing professional, working relatively independently from a physician, compared to traditional care provided by a physician. Our scope included all outpatient care for asthma, both in primary care and in hospital settings.

Search methods: We carried out a comprehensive search of databases including The Cochrane Library, MEDLINE and EMBASE to identify trials up to August 2012. Bibliographies of relevant papers were searched, and handsearching of relevant publications was undertaken to identify additional trials.

Selection criteria: Randomised controlled trials comparing nurse-led care versus physician-led care in asthma for the same aspect of asthma care.

Data collection and analysis: We used standard methodological procedures expected by The Cochrane Collaboration.

Main results: Five studies on 588 adults and children were included concerning nurse-led care versus physician-led care. One study included 154 patients with uncontrolled asthma, while the other four studies including 434 patients with controlled or partly controlled asthma. The studies were of good methodological quality (although it is not possible to blind people giving or receiving the intervention to which group they are in). There was no statistically significant difference in the number of asthma exacerbations and asthma severity after treatment (duration of follow-up from six months to two years). Only one study had healthcare costs as an outcome parameter, no statistical differences were found. Although not a primary outcome, quality of life is a patient-important outcome and in the three trials on 380 subjects that reported on this outcome, there was no statistically significant difference (standardised mean difference (SMD) -0.03; 95% confidence interval (CI) -0.23 to 0.17).

Authors' conclusions: We found no significant difference between nurse-led care for patients with asthma compared to physician-led care for the outcomes assessed. Based on the relatively small number of studies in this review, nurse-led care may be appropriate in patients with well-controlled asthma. More studies in varied settings and among people with varying levels of asthma control are needed with data on adverse events and health-care costs.

PubMed Disclaimer

Conflict of interest statement

  1. None known.

Figures

1
1
Flow diagram.
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
3
3
Forest plot of comparison: 1 Nurse‐led versus physician‐led, outcome: 1.1 Quality of life at 12 months.
4
4
Forest plot of comparison: 1 Nurse‐led versus physician‐led, outcome: 1.2 Hospital admission.
5
5
Forest plot of comparison: 1 Nurse‐led versus physician‐led, outcome: 1.4 Hospital admission subgroup analysis.
6
6
Forest plot of comparison: 1 Nurse‐led versus physician‐led, outcome: 1.3 FEV1 % predicted.
1.1
1.1. Analysis
Comparison 1 Nurse‐led versus physician‐led care for the management of asthma, Outcome 1 Quality of life at 12 months.
1.2
1.2. Analysis
Comparison 1 Nurse‐led versus physician‐led care for the management of asthma, Outcome 2 Hospital admission.
1.3
1.3. Analysis
Comparison 1 Nurse‐led versus physician‐led care for the management of asthma, Outcome 3 FEV1 % predicted.
1.4
1.4. Analysis
Comparison 1 Nurse‐led versus physician‐led care for the management of asthma, Outcome 4 Hospital admission subgroup analysis.

Update of

References

References to studies included in this review

Kamps 2003 {published data only}
    1. Kamps AW, Brand PL, Kimpen JL, Maille AR, Overgoor‐van de Groes AW, Helsdingen‐Peek LC, et al. Outpatient management of childhood asthma by paediatrician or asthma nurse: randomised controlled study with one year follow up. Thorax 2003;58(11):968‐73. - PMC - PubMed
    1. Kamps AW, Roorda RJ, Kimpen JL, Overgoor‐van de Groes AW, Helsdingen LC, Brand PLP. Impact of nurse‐led outpatient management of children with asthma on healthcare resource utilisation and costs. European Respiratory Journal 2004;23(2):304‐9. - PubMed
Kuethe 2011 {published data only}
    1. Kuethe M, Vaessen‐Verberne A, Mulder P, Bindels P, Aalderen W. Paediatric asthma outpatient care by asthma nurse, paediatrician or general practitioner: randomised controlled trial with two‐year follow‐up. Primary Care Respiratory Journal 2011;20(1):84‐91. - PMC - PubMed
    1. Kuethe MC, Sixma HJ, Vaessen‐Verberne AAPH, Booij JC, van Aalderen, WMC. Assessing quality of care in pediatric asthma: applicability of a revised version of the QUOTE‐CNSLD Questionnaire. Journal of Asthma 2012;Early Online:1‐11. - PubMed
Nathan 2006 {published data only}
    1. Laroche C, Pearce L, Sipmson T, Hawkes J, Webb M, Sharples L. A randomised trial of the effectiveness of early follow‐up by a respiratory consultant or a respiratory specialist nurse on asthma readmission. European Respiratory Journal 2000;16 Suppl 31:7s‐8s.
    1. Nathan JA, Pearce L, Field C, Dotesio‐Eyres N, Sharples LD, Cafferty F, et al. A randomized controlled trial of follow‐up of patients discharged from the hospital following acute asthma: best performed by specialist nurse or doctor?. Chest 2006;130(1):51‐7. - PubMed
Pilotto 2004 {published data only}
    1. Pilotto LS, Smith BJ, Heard AR, McElroy HJ, Weekley J, Bennett P. Trial of nurse‐run asthma clinics based in general practice versus usual medical care. Respirology 2004;9(3):356‐62. - PubMed
van Son 2004 {published data only}
    1. Son L, Vrijhoef H, Crebolder H, Hoef L, Beusmans G. Support for the general practitioner. An exploration of the effect of the practice nurse on the care of asthma, COPD and diabetes patients [De huisarts ondersteund. een RCT naar het effect van een praktijkondersteuner bij astma, copd en diabetes]. Huisarts en Wetenschap 2004;47(1):15‐21.

References to studies excluded from this review

Alexander 1988 {published data only}
    1. Alexander JS, Younger RE, Cohen RM, Crawford LV. Effectiveness of a nurse‐managed program for children with chronic asthma. Journal of Pediatric Nursing 1988;3(5):312‐17. - PubMed
Castro 2003 {published data only}
    1. Castro M, Zimmermann NA, Crocker S, Bradley J, Leven C, Schechtman KB. Asthma intervention program prevents readmissions in high healthcare users. American Journal of Respiratory and Critical Care Medicine 2003;168(9):1095‐99. - PubMed
Catrambone 2000 {published data only}
    1. Catrambone CD. Effect of a case management intervention on symptoms of asthma in high risk children [Dissertation]. Rush University, College of Nursing, 2000.
Cave 2001 {published data only}
    1. Cave AJ, Wright A, Dorrett J, McErlain M. Evaluation of a nurse‐run asthma clinic in general practice. Primary Care Respiratory Journal 2001;10(3):65‐8. - PMC - PubMed
Charlton 1991 {published data only}
    1. Charlton I, Charlton G, Broomfield J, Mullee MA. Audit of the effect of a nurse run asthma clinic on workload and patient morbidity in a general practice. British Journal of General Practice 1991;41(347):227‐31. - PMC - PubMed
Charlton 1994 {published data only}
    1. Charlton I, Antoniou AG, Atkinson J, Campbell MJ, Chapman E, Mackintosh T, et al. Asthma at the interface: bridging the gap between general practice and a district general hospital. Archives of Diseases in Childhood 1994;70(4):313‐18. - PMC - PubMed
Dickinson 1997 {published data only}
    1. Dickinson J, Hutton S, Atkin A, Jones K. Reducing asthma morbidity in the community: the effect of a targeted nurse‐run asthma clinic in an English general practice. Respiratory Medicine 1997;91(10):634‐40. - PubMed
Grieneder 1999 {published data only}
    1. Greineder DK, Loane KC, Parks P. A randomized controlled trial of a pediatric asthma outreach program. Journal of Allergy & Clinical Immunology 1999;103(3 pt 1):436‐40. - PubMed
Griffiths 2004 {published data only}
    1. Griffiths C, Foster G, Barnes N, Eldridge S, Tate H, Begum S, et al. Specialist nurse intervention to reduce unscheduled asthma care in a deprived multiethnic area: the east London randomised controlled trial for high risk asthma (ELECTRA). BMJ 2004;328(7432):144. - PMC - PubMed
Hughes 1991 {published data only}
    1. Hughes DM, McLeod M, Garner B, Goldbloom RB. Controlled trial of a home and ambulatory program for asthmatic children. Pediatrics 1991;87(1):54‐61. - PubMed
Jones 1995 {published data only}
    1. Jones KP, Mullee MA. Proactive, nurse‐run asthma care in general practice reduces asthma morbidity: scientific fact or medical assumption?. British Journal of General Practice 1995;45(389):497‐99. - PMC - PubMed
Kernick 2002 {published data only}
    1. Kernick D, Powell R, Reinhold D. A pragmatic randomised controlled trial of an asthma nurse in general practice. Primary Care Respiratory Journal 2002;11(1):6‐8. - PMC - PubMed
Lenz 2004 {published data only}
    1. Lenz ER, Mundinger MO, Kane RL, Hopkins SC, Lin SX. Primary care outcomes in patients treated by nurse practitioners or physicians: two‐year follow‐up. Medical Care Research and Review 2004;61(3):331‐51. - PubMed
Levy 2000 {published data only}
    1. Levy ML, Robb M, Allen J, Doherty C, Bland JM, Winter RJ. A randomized controlled evaluation of specialist nurse education following accident and emergency department attendance for acute asthma. Respiratory Medicine 2000;94(9):900‐8. - PubMed
Lindberg 2002 {published data only}
    1. Lindberg M, Ahlner J, Ekstrom T, Jonsson D, Moller M. Asthma nurse practice improves outcomes and reduces costs in primary health care. Scandinavian Journal of Caring Sciences 2002;16(1):73‐8. - PubMed
Mundinger 2000 {published data only}
    1. Mundinger MO, Kane RL, Lenz ER, Totten AM, Tsai WY, Cleary PD, et al. Primary care outcomes in patients treated by nurse practitioners or physicians. JAMA 2000;238(1):59‐68. - PubMed
Webb 1997 {published data only}
    1. Webb JR, Brooks S, Goddard J, Meighan‐Davies J, Hooper F, Oldind A. Asthma Nurse Specialist (ANS) Intervention in the Management of Asthma: the Asthma Resource project (ARC) in Greenwich. Thorax 1997;52(Suppl 6):A46.
Weng 2007 {published data only}
    1. Weng HC, Yuan BC, Su YT, Perng DS, Chen WH, Lin LJ, et al. Effectiveness of a nurse‐led management programme for paediatric asthma in Taiwan. Journal of Paediatrics & Child Health 2007;43(3):134‐8. - PubMed

Additional references

Akinbami 2009
    1. Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980‐2007. Pediatrics 2009;123(Suppl 3):S131‐45. - PubMed
Barley 1998
    1. Barley EA, Quirk FH, Jones PW. Asthma health status measurement in clinical practice: validity of a new short and simple instrument. Respiratory Medicine 1998;92:1207‐14. - PubMed
CAMP 2000
    1. The Childhood Asthma Management Program Research Group. Long‐term effect of budesonide or nedocromil in children with asthma. New England Journal of Medicine 2000;343(15):1054‐63. - PubMed
de Jongste 2007
    1. Jongste JC, Vrijlandt EL. Pediatric Asthma; Revised Guidelines of the Pediatric Pulmonology Group of the Dutch Society of Pediatricians. Amsterdam: Jurriaans Lindenbaum Grafimedia, 2007. [ISBN/EAN: 978‐90‐9023508‐0]
Gibson 2008
    1. Gibson PG, Powell H, Wilson A, Hensley MJ, Abramson MJ, Bauman A, et al. Limited (information only) patient education programs for adults with asthma. Cochrane Database of Systematic Reviews 2002, Issue 1. [DOI: 10.1002/14651858.CD001005] - DOI - PubMed
Gibson 2009
    1. Gibson PG, Powell H, Wilson A, Abramson MJ, Haywood P, Bauman A, et al. Self‐management education and regular practitioner review for adults with asthma. Cochrane Database of Systematic Reviews 2002, Issue 3. [DOI: 10.1002/14651858.CD001117] - DOI - PMC - PubMed
GINA 2011
    1. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention (updated 2011): Global Initiative for asthma (GINA), 2011. www.ginasthma.org. (accessed 13 December 2012).
Grade Working Group 2004
    1. Atkins D, Best D, Briss PA, Eccles M, Falck‐Ytter Y, Flottorp S, et al. Grading quality of evidence and strength of recommendations. BMJ 2004;328(7454):1490. - PMC - PubMed
Guarnaccia 2007
    1. Guarnaccia S, Lombardi A, Gaffurini A, Chiarini M, Domenighini S, D'Agata E, et al. Application and implementation of the GINA asthma guidelines by specialist and primary care physicians: a longitudinal follow‐up study on 264 children. Primary Care Respiratory Journal 2007;16(6):357‐62. - PMC - PubMed
Higgins 2011
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org.
Jones 1991
    1. Jones PW, Quirk FH, Baveystock CM. The St Georges Respiratory Questionnaire. Respiratory Medicine 1991;85(suppl B):25‐31. - PubMed
Jones 2009
    1. Jones A, Fay JK, Ram FSF. Primary care based clinics for asthma. Cochrane Database of Systematic Reviews 2009, Issue 4. [DOI: 10.1002/14651858.CD003533] - DOI - PubMed
Juniper 1993
    1. Juniper EF, Guytt GH, Ferrie PJ, Griffith LE. Measuring quality of life in asthma. American Review of Respiratory Disease 1993;147:832‐8. - PubMed
Juniper 1996a
    1. Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in children with asthma. Quality of Life Research 1996;5:35‐46. - PubMed
Juniper 1996b
    1. Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in the caregivers of children with asthma. Quality of Life Research 1996;5:27‐34. - PubMed
Juniper 1999
    1. Juniper EF, O'Byrne PM, Guyatt GH, King DR. Development and validation of a questionnaire to measure asthma control. European Respiratory Journal 1999;14:902‐7. - PubMed
Juniper 2006
    1. Juniper EF, Bousquet J, Abetz L, Bateman ED, the GOAL Committee. Identifying "well‐controlled" asthma using the Asthma Control Questionnaire. Respiratory Medicine 2006;100:616‐21. - PubMed
Laurant 2005
    1. Laurant M, Reeves D, Hermens R, Braspenning J, Grol R, Sibbald B. Substitution of doctors by nurses in primary care. Cochrane Database of Systematic Reviews 2004, Issue 4. [DOI: 10.1002/14651858.CD001271.pub2] - DOI - PubMed
Levy 2009
    1. Levy ML, Thomas M, Small I, Pearce L, Pinnock H, Stephenson P. Summary of the 2008 BTS/SIGN British Guideline on the management of asthma. Primary Care Respiratory Journal 2009;18(Suppl 1):S1‐16. - PMC - PubMed
Loveman 2003
    1. Loveman E, Royle P, Waugh N. Specialist nurses in diabetes mellitus. Cochrane Database of Systematic Reviews 2003, Issue 2. [DOI: 10.1002/14651858.CD003286] - DOI - PMC - PubMed
Nelson 1990
    1. Nelson EC, Landgraf JM, Hays RD, Wasson JH, Kirk JW. The functional status of patient. How can it be measured in physicians' offices. Medical Care 1990;12:1111‐26. - PubMed
O'Byrne 2006
    1. O'Byrne PM. Asthma Management Guidelines: the issue of implementation. Primary Care Respiratory Journal 2006;15(1):5‐6. - PMC - PubMed
Post 1998a
    1. Post MWM, Kuyvenhoven MM, Verheij ThJM, Melker RA, Hoes AW. The Dutch version of 'Functional Status II(R)': a questionnaire measuring the functional health status of children [De Nederlandse "Functional status II(R); een vragenlijst voor het meten van de functionele gezondheidstoestand van kinderen]. Ned Tijdschr Geneeskunde 1998;5(142):2675‐9. - PubMed
Post 1998b
    1. Post MWM, Kuyvenhoven MM, Verheij ThJM, Melker RA, Hoes AW. The Dutch 'Rand General Health Rating Index for Children': a questionnaire measuring the general health status of children. [De Nederlandse "RAND general health rating index for children"; een meetinstrument voor de algemene gezondheid van kinderen.]. Ned Tijdschr Geneeskunde 1998;5(142):2680‐3. - PubMed
RevMan 2008 [Computer program]
    1. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Schatz 2006
    1. Schatz M, Sorkness CA, Li JT, Marcus P, Murray JJ, Nathan RA, et al. Asthma Control Test: reliability, validity and responsiveness in patients not previously followed by asthma specialists. Journal of Allergy & Clinical Immunology 2006;117(3):549‐56. - PubMed
Sharples 2002
    1. Sharples LD, Edmunds J, Bilton D, Hollingworth W, Caine N, Keogan M, et al. A randomised controlled crossover trial of nurse practitioner versus doctor led outpatient care in a bronchiectasis clinic. Thorax 2002;57:661‐66. - PMC - PubMed
SIGN 2011
    1. Scottish Intercollegiate Guidelines Network (SIGN). British Guideline on the Management of Asthma, 2011. www.sign.ac.uk/guidelines/fulltext/101/index.html. (accessed 13 December 2012).
Stein 1990
    1. Stein REK, Jessop JD. Functional Status II(R): a measure of child health status. Medical Care 1990;28(11):1041‐55. - PubMed
Taylor 2005
    1. Taylor SJC, Candy B, Bryar RM, Ramsay J, Vrijhoef HJM, Esmond G, et al. Effectiveness of innovations in nurse led chronic disease management for patients with chronic obstructive pulmonary disease: systematic review of evidence. BMJ 2005;331:485. - PMC - PubMed
Tsai 2005
    1. Tsai AC, Morton SC, Mangione CM, Keeler EB. A meta‐analysis of interventions to improve care for chronic illnesses. American Journal of Managed Care 2005;11(8):478‐88. - PMC - PubMed
van Campen 1997
    1. Campen C, Sixma HJ, Kerssens JJ, Peters L. Assessing noninstitutionalized asthma and COPD patients' priorities and perceptions of quality of health care: the development of the QUOTE‐CNSLD instrument. Journal of Asthma 1997;6(34):531‐8. - PubMed
van Weel 1990
    1. Weel C, Meyboom B, Weert H. The functioning of patients, clinimetry in primary care [Het functioneren van de patient, klinimetrie in de huisartsen praktijk]. Ned Tijdschrift voor Geneeskunde 1990;134(21):1039. - PubMed
Wenzel 2006
    1. Wenzel SE, Covar R. Update in asthma 2005. American Journal of Respiratory & Critical Care Medicine 2006;173(7):698‐706. - PubMed
Wolf 2008
    1. Wolf F, Guevara JP, Grum CM, Clark NM, Cates CJ. Educational interventions for asthma in children. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD000326] - DOI - PubMed

References to other published versions of this review

Kuethe 2011
    1. Kuethe MC, Vaessen‐Verberne AAPH, Elbers GM, Aalderen MC. Nurse versus physician led care for the management of asthma. Cochrane Database of Systematic Reviews 2011, Issue 9. [DOI: 10.1002/14651858.CD009296] - DOI - PMC - PubMed

Publication types