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. 2013 Apr 2;19(14):4437-40.
doi: 10.1002/chem.201204633. Epub 2013 Feb 28.

Selective ruthenium-catalyzed transfer hydrogenations of nitriles to amines with 2-butanol

Svenja Werkmeister  1 , Christoph Bornschein, Kathrin Junge, Matthias Beller
Affiliations

Selective ruthenium-catalyzed transfer hydrogenations of nitriles to amines with 2-butanol

Svenja Werkmeister et al. Chemistry. .

Abstract

Transfer your hydrogen: Fast and general transfer hydrogenation of nitriles to form primary amines is possible with a homogeneous Ru/1,4-bis(diphenylphosphino)butane (DPPB) catalyst (see scheme). The use of 2-butanol as the hydrogen-transfer reagent is essential for the selective reduction of aromatic, heteroaromatic, and aliphatic nitriles with this system.

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