Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar 4:12:41.
doi: 10.1186/1475-2840-12-41.

Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

Ki-Bum Won  1 , Hyuk-Jae Chang, Hyeon-Chang Kim, Kyewon Jeon, Hancheol Lee, Sanghoon Shin, In-Jeong Cho, Sung-Ha Park, Sang-Hak Lee, Yangsoo Jang
Affiliations

Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

Ki-Bum Won et al. Cardiovasc Diabetol. .

Abstract

Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.

Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.

Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).

Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of SCA parameters according to the presence of MS and diabetes. (a) baPWV, (b) carotid IMT. DM, diabetes mellitus.
Figure 2
Figure 2
Correlations between the number of MS components, and baPWV and carotid IMT. (a) Non-diabetics, (b) diabetics.
See this image and copyright information in PMC

References

    1. NCEP. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) J Am Med Assoc. 2001;285:2486–2497. doi: 10.1001/jama.285.19.2486. - DOI - PubMed
    1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation. 2005;112:2735–2752. doi: 10.1161/CIRCULATIONAHA.105.169404. - DOI - PubMed
    1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults. J Am Med Assoc. 2002;287:356–359. doi: 10.1001/jama.287.3.356. - DOI - PubMed
    1. Park JS, Park HD, Yun JW, Jung CH, Lee WY, Kim SW. Prevalence of the metabolic syndrome as defined by NCEP-ATPIII among the urban Korean population. Korean J Med. 2002;63:290–298.
    1. Klein BE, Klein R, Lee KE. Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in beaver Dam. Diabetes Care. 2002;25:1790–1794. doi: 10.2337/diacare.25.10.1790. - DOI - PubMed

Publication types