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. 2013 Mar 1:8:34.
doi: 10.1186/1749-8090-8-34.

Intracellular lactate signaling cascade in atrial remodeling of mitral valvular patients with atrial fibrillation

Jing Xu  1 , Xiaohan Xu, Linjie Si, Lei Xue, Shijiang Zhang, Jianwei Qin, Yanhu Wu, Yongfeng Shao, Yijiang Chen, Xiaowei Wang
Affiliations

Intracellular lactate signaling cascade in atrial remodeling of mitral valvular patients with atrial fibrillation

Jing Xu et al. J Cardiothorac Surg. .

Abstract

Background: Atrial remodeling has emerged as the structural basis for the maintenance and recurrence of atrial fibrillation. Lactate signaling cascade was recently linked to some cardiovascular disorders for its regulatory functions to myocardial structural remodeling. It was hypothesized that lactate signaling cascade was involved in the maintenance and recurrence of atrial fibrillation by regulating atrial structural remodeling.

Methods: Biopsies of right atrial appendage and clinical data were collected from sex- and age-matched 30 persistent atrial fibrillation, 30 paroxysmal atrial fibrillation, 30 sinus rhythm patients undergoing isolated mitral valve surgery and 10 healthy heart donors.

Results: Atrial fibrillation groups had higher atrial lactate expression and this upregulated expression was positively correlated with regulatory indicators of atrial structural remodeling as reflected by severe oxidative stress injury and mitochondrial control of apoptosis.

Conclusions: The present findings suggest a potential role for lactate signaling cascade in the maintenance and recurrence of atrial fibrillation and possibly represent new targets for therapeutic intervention in this disorder.

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Figures

Figure 1
Figure 1
The expression of lactate in RAA tissues.
Figure 2
Figure 2
The protein expression of MCT1 in mitochondrial membrane. (A) Representative MCT1 and COx immunoblotting were shown in NC, SR, PaAF and PeAF groups (B) The different levels of MCT1/ Cox were determined among above-mentioned groups.
Figure 3
Figure 3
The level of ROS in RAA tissues by TBARS.
Figure 4
Figure 4
The proteins expression of mitochondrial apoptosis pathway in RAA tissues. (A) Representative cyto c, cleaved-caspase 9, cleaved-caspase 3 and GAPDH immunoblotting were shown in NC, SR, PaAF and PeAF groups. The different levels of cyto c/GAPDH (B), cleaved-caspase 9/GAPDH (C), cleaved-caspase 3/GAPDH (D) were determined respectively among above-mentioned groups.
Figure 5
Figure 5
The simplified scheme of interactions within lactate signalling cascade.
See this image and copyright information in PMC

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