Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Mar 1:2013:bcr2013008743.
doi: 10.1136/bcr-2013-008743.

Haemophagocytic syndrome with disseminated intravascular coagulation associated with tuberculosis

Eya Cherif  1 , Nabil Bel Feki, Lamia Ben Hassine, Narjess Khalfallah
Affiliations
Case Reports

Haemophagocytic syndrome with disseminated intravascular coagulation associated with tuberculosis

Eya Cherif et al. BMJ Case Rep. .

Abstract

Haemophagocytic syndrome (HPS) is a clinical entity that combines non-specific clinical and biological features. The diagnosis is usually confirmed by a bone marrow examination. HPS may be primary or secondary to a malignancy or to an infectious or autoimmune disease. Early aggressive survey of the aetiology and optimal treatment of the underlying disease improve the outcome of life-threatening HPS. Infection-associated HPS occurs predominantly in immunocompromised patients and is usually fatal. Leading trigger agents are viruses, especially the Epstein-Barr virus and cytomegalovirus. Mycobacterial infections associated with HPS are rare but should be considered in those patients where there is associated fever of unknown origin. We present a case of disseminated tuberculosis-associated HPS.

PubMed Disclaimer

Figures

Figure 1
Figure 1
CT of the chest demonstrates bilateral diffuse infiltrates of lungs.
See this image and copyright information in PMC

References

    1. Glasser RM, Walker RI, Herion JC. The significance of hematologic abnormalities in patients with tuberculosis. Arch Intern Med 1970;125:691–5 - PubMed
    1. Fujita M, Kunitake R, Nagano Y, et al. Disseminated intravascular coagulation associated with pulmonary tuberculosis. Intern Med 1997;36:218–20 - PubMed
    1. Brastianos PK, Swanson JW, Torbenson M, et al. Tuberculosis-associated hemophagocytic syndrome. Lancet Infect Dis 2006;6:447–54 - PubMed
    1. Lee SW, Wang CY, Lee BJ, et al. Hemophagocytic syndrome in miliary tuberculosis presenting with noncaseating granulomas in bone marrow and liver. J Formos Med Assoc 2008;107:495–9 - PubMed
    1. Larroche C. Hemophagocytic lymphohistiocytosis in adults: Diagnosis and treatment. Joint Bone Spine 2012;79:356–61 - PubMed

Publication types

Substances