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Review
. 2013:785:77-86.
doi: 10.1007/978-1-4614-6217-0_9.

Memory CD8⁺ T cell protection

Sanda Remakus  1 , Luis J Sigal
Affiliations
Review

Memory CD8⁺ T cell protection

Sanda Remakus et al. Adv Exp Med Biol. 2013.

Abstract

Memory CD8⁺ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8⁺ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8⁺ T cell response will help optimize vaccine-induced CD8⁺ T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8⁺ T cells may affect the primary response.

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