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. 2014 Jan;31(1):69-76.
doi: 10.1055/s-0033-1334451. Epub 2013 Mar 1.

Maternal genotype and gestational diabetes

Alison M Stuebe  1 , Alison Wise  2 , Thutrang Nguyen  3 , Amy Herring  2 , Kari E North  4 , Anna Maria Siega-Riz  4
Affiliations

Maternal genotype and gestational diabetes

Alison M Stuebe et al. Am J Perinatol. 2014 Jan.

Abstract

Objective: To determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM).

Study design: We genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations.

Results: GDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8 rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1 rs864745 T allele.

Conclusion: We found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance.

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

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