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Review
. 2013 Mar 1;22(127):44-52.
doi: 10.1183/09059180.00007112.

Adult-onset asthma: is it really different?

Selma B de Nijs  1 , Lisette N Venekamp, Elisabeth H Bel
Affiliations
Review

Adult-onset asthma: is it really different?

Selma B de Nijs et al. Eur Respir Rev. .

Erratum in

  • Eur Respir Rev. 2013 Jun 1;22(128):193

Abstract

Asthma that starts in adulthood differs from childhood-onset asthma in that it is often non-atopic, more severe and associated with a faster decline in lung function. Understanding of the underlying mechanism of adult-onset asthma and identification of specific phenotypes may further our understanding of pathophysiology and treatment response, leading to better targeting of both existing and new approaches for personalised management. Pivotal studies in past years have led to sustained progress in many areas, ranging from risk factors for development, identification of different phenotypes, and introduction of new therapies. This review highlights and discusses literature on adult-onset asthma, with special focus on the differences from childhood-onset asthma, risk factors for development, phenotypes of adult-onset asthma and new approaches for personalised management.

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Conflict of interest statement

Statement of Interest

E.H. Bel has received, on behalf of the Department of Respiratory Medicine of the Academic Medical Centre, grant monies from GSK, Novartis and Chiesi; consultancy fees from Actelion, Merck, Schering Plough and GSK; and fees for speaking from GSK, Novartis and Nycomed.

References

    1. Eagan TM, Brogger JC, Eide GE, et al. . The incidence of adult asthma: a review. Int J Tuberc Lung Dis 2005; 9: 603–612. - PubMed
    1. Masoli M, Fabian D, Holt S, et al. . The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004; 59: 469–478. - PubMed
    1. Haldar P, Pavord ID, Shaw DE, et al. . Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178: 218–224. - PMC - PubMed
    1. Moore WC, Meyers DA, Wenzel SE, et al. . Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181: 315–323. - PMC - PubMed
    1. ten Brinke A, van Dissel JT, Sterk PJ, et al. . Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection. J Allergy Clin Immunol 2001; 107: 449–454. - PubMed

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