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Editorial
. 2013 Jan-Feb;20(1):27-9.
doi: 10.1155/2013/509130.

Oxidative stress in chronic obstructive pulmonary disease: a lung and systemic process

Stephan F van Eeden, Don D Sin
Editorial

Oxidative stress in chronic obstructive pulmonary disease: a lung and systemic process

Stephan F van Eeden et al. Can Respir J. 2013 Jan-Feb.
No abstract available

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Figures

Figure 1)
Figure 1)
Oxidant/antioxidant imbalance in subjects exposed to inhaled oxidants such as cigarette smoke and environmental pollutants. Both oxidants generated from inhaled oxidants and by inflammatory cells in the lung contribute to a burden of reactive oxygen species (ROS) and reactive nitrogen species (RNS). The ROS and RNS deplete the normal antioxidant defenses (such as glutathione) of the lung, and activate redox-sensitive transcription factors that act as signalling molecules to perpetuate the inflammatory response in the lung. Collectively, this produces a pro-oxidative/proinflammatory state in the lung that promote the translocation or ‘spill over’ of oxidants and proinflammatory mediators into the circulation
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