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. 1990 Apr;68(1):125-8.

Evidence for a factor protective against hypoxic liver parenchymal cell injury in a protein-free blood extract

H de Groot  1 , M Brecht, F Machicao
Affiliations
  • PMID: 2345803

Evidence for a factor protective against hypoxic liver parenchymal cell injury in a protein-free blood extract

H de Groot et al. Res Commun Chem Pathol Pharmacol. 1990 Apr.

Abstract

The effect of a protein-free extract from calf blood on hypoxic cell injury was studied in experiments with primary cultures of isolated hepatocytes. At concentrations above 1 mg/ml the extract produced marked protection. At 4 h of anaerobic incubation at 37 degrees C only 20% of cells were damaged as compared to 50% of the anaerobic control incubation. These data demonstrate the presence of a factor in the blood extract which protects against hypoxic cell injury.

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