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Review
. 2013 Mar;34(3):329-35.
doi: 10.1038/aps.2013.6.

hERG channel function: beyond long QT

Joseph J Babcock  1 , Min Li
Affiliations
Review

hERG channel function: beyond long QT

Joseph J Babcock et al. Acta Pharmacol Sin. 2013 Mar.

Abstract

To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.

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Figures

Figure 1
Figure 1
Diversity of tissue expression and regulation of cardiac potassium channels. A) The fraction of samples expressing (gene present/absent) hERG (KCNH2), KCNQ1, Kir2.1 (KCNJ2), or hEAG (KCNH1) channels in Unigene EST profiles for tissues, tumors, and developmental stages. Parentheses indicate the number of samples in each profile class. B) The number of EBI Gene Expression Atlas experiments showing differential expression (transcript regulated up/down) of cardiac potassium channels across five experimental classes.
See this image and copyright information in PMC

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