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. 2013 Sep;288(3):501-5.
doi: 10.1007/s00404-013-2774-3. Epub 2013 Mar 5.

The role of apoptosis in preterm premature rupture of the human fetal membranes

Aylin Saglam  1 , Cinar Ozgur, Iris Derwig, Bekir Serdar Unlu, Funda Gode, Tamer Mungan
Affiliations

The role of apoptosis in preterm premature rupture of the human fetal membranes

Aylin Saglam et al. Arch Gynecol Obstet. 2013 Sep.

Abstract

Purpose: The present study was designed to examine apoptotic cell death via the caspase-dependent pathway in human fetal membranes.

Methods: Amniotic membrane samples were collected from three groups of women: group 1, women with preterm premature rupture of fetal membranes (PPROM) after cesarean delivery (n = 10), group 2, women with preterm labor (PTL) with intact membranes after cesarean delivery (n = 9) and group 3, women with term labor and vaginal delivery after an uncomplicated pregnancy (controls) (n = 11).

Results: Active caspase-3 immunopositivity (ACPI) of the PPROM group was significantly higher than that of the control group (p < 0.05). ACPI was higher in the PTL with intact membranes group as compared to the control group; however, it did not reach statistical significance (p > 0.05).

Conclusion: Active caspase-3 positivity is increased in the fetal membranes of those women with PPROM.

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