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Case Reports
. 2013 Apr;54(4):485-90.
doi: 10.1007/s00108-013-3246-3.

[Drug-induced malignant arrhythmias. IT prevents lethal drug mixtures]

[Article in German]
S Thaler  1 , C Neumeier, G Flury
Affiliations
Case Reports

[Drug-induced malignant arrhythmias. IT prevents lethal drug mixtures]

[Article in German]
S Thaler et al. Internist (Berl). 2013 Apr.

Abstract

We report a case of nearly fatal ventricular tachyarrhythmia type Torsade de pointes caused by medication-induced prolongation of QTc duration (methadone, ondansetron, escitalopram). The etiology, pathophysiology, and trigger mechanisms of such malignant arrhythmias are discussed. In order to prevent similar iatrogenic complications in the future, we networked the qtdrug database with our medication interaction control program and installed an automatic electronic warning system for the physicians in charge in case of a digitally recorded prolonged QTc duration.

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