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. 2013 Apr 1;190(7):3613-9.
doi: 10.4049/jimmunol.1202507. Epub 2013 Mar 4.

Novel function of Trim44 promotes an antiviral response by stabilizing VISA

Bo Yang  1 , Jie Wang, Yanming Wang, Haiyan Zhou, Xiaodong Wu, Zhigang Tian, Bing Sun
Affiliations

Novel function of Trim44 promotes an antiviral response by stabilizing VISA

Bo Yang et al. J Immunol. .

Abstract

Virus-induced signaling adaptor (VISA) functions as a critical adaptor in the regulation of both the production of type I IFNs and the subsequent control of the innate antiviral response. In this study, we demonstrate that tripartite motif (Trim)44 interacts with VISA and promotes VISA-mediated antiviral responses. The overexpression of Trim44 enhances the cellular response to viral infection, whereas Trim44 knockdown yields the opposite effect. Trim44 stabilizes VISA by preventing VISA ubiquitination and degradation. These findings suggest that Trim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA.

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