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Review
. 2013 Feb 1;9(1):15-9.
doi: 10.2174/157340313805076304.

Risk factors in cardiovascular disease in systemic lupus erythematosus

Nailú Angélica Sinicato  1 , Priscila Aparecida da Silva Cardoso, Simone Appenzeller
Affiliations
Review

Risk factors in cardiovascular disease in systemic lupus erythematosus

Nailú Angélica Sinicato et al. Curr Cardiol Rev. .

Abstract

Systemic lupus erythematosus (SLE) is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in SLE patients affected by disease for more than 5 years is cardiovascular disease (CVD). Epidemiological observations suggest that, together with classical conventional risk factors, other mechanisms (non-conventional/disease-specific factors) promote accelerated atherosclerosis in inflammatory diseases like SLE. Traditional CVD risk factors included age, hypertension, diabetes mellitus, dyslipidemia, previous vascular event defined as previous history of cerebrovascular accidents or ischemic heart disease, menopause and smoking. The nontraditional factors presents in SLE are disease-specific like renal disease manifestation as Lupus nephritis (LN), presence of pro-inflammatory cytokines, some of inflammatory mediators, antiphospholipid antibodies, anti-oxLDL antibodies, corticosteroid uses and cumulative dose of glucocorticoids. We will review traditional and non-traditional risk factors associated with CVD in SLE patients.

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Figures

Fig. (1)
Fig. (1)
Traditional and non-traditional risk factors for cardiovascular disease in SLE.
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References

    1. Foster MH. T cells and B cells in lupus nephritis. Semin Nephrol. 2007;27:47–58. - PMC - PubMed
    1. Danchenko N, Satia JA, Anthony MS. Epidemiology of systemic lupus erythematosus a comparison of worldwide disease burden. Lupus. 2006;15:308–18. - PubMed
    1. Merrell M, Shulman LE. Determination of prognosis in chronic disease, illustrated by systemic lupus erythematosus. J Chronic Dis. 1955;1:12–32. - PubMed
    1. Svenungsson E, Jensen-Urstad K, Heimburger M, Silveira A, Hamsten A, Hamsten , et al. Risk factors for cardiovascular disease in systemic lupus erythematosus. Circulation. 2001;104:1887–93. - PubMed
    1. Haque S, Bruce IN. Therapy insight systemic lupus erythematosus as a risk factor for cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2005;2:423–30. - PubMed

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