Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr 1;23(7):2052-5.
doi: 10.1016/j.bmcl.2013.02.009. Epub 2013 Feb 13.

Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones

Derek J Denhart  1 , Dmitry Zuev, Jonathan L Ditta, Richard A Hartz, Vijay T Ahuja, Ronald J Mattson, Hong Huang, Gail K Mattson, Larisa Zueva, Julia M Nielsen, Edward S Kozlowski, Nicholas J Lodge, Joanne J Bronson, John E Macor
Affiliations

Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones

Derek J Denhart et al. Bioorg Med Chem Lett. .

Abstract

A series of pyrazinones were prepared and evaluated as potential CRF(1)R PET imaging agents. Optimization of their CRF(1)R binding potencies and octanol-phosphate buffer phase distribution coefficients are discussed herein.

PubMed Disclaimer

Substances

LinkOut - more resources