Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb;25(1):17-22.
doi: 10.5021/ad.2013.25.1.17. Epub 2013 Feb 14.

The Clinical Efficacy of Mometasone Furoate in Multi-Lamellar Emulsion for Eczema: A Double-blinded Crossover Study

Duk Han Kim  1 , Hyun Jong Lee, Chun Wook Park, Kyu Han Kim, Kwang Hoon Lee, Byung In Ro, Sang Hyun Cho
Affiliations

The Clinical Efficacy of Mometasone Furoate in Multi-Lamellar Emulsion for Eczema: A Double-blinded Crossover Study

Duk Han Kim et al. Ann Dermatol. 2013 Feb.

Abstract

Background: Topical application of corticosteroids also has an influence on skin barrier impairment. Physiological lipid mixtures, such as multi-lamellar emulsion (MLE) containing a natural lipid component leads to effective recovery of the barrier function.

Objective: The purpose of this study was to conduct an evaluation of the therapeutic efficacy and skin barrier protection of topical mometasone furoate in MLE.

Methods: A multi-center randomized, double-blind, controlled study was performed to assess the efficacy and safety of mometasone furoate cream in MLE for Korean patients with eczema. The study group included 175 patients with eczema, who applied either mometasone furoate in MLE cream or methylprednisolone aceponate cream for 2 weeks. Treatment efficacy was evaluated using the physician's global assessment of clinical response (PGA), trans-epidermal water loss (TEWL), and visual analogue scale (VAS) for pruritus. Patients were evaluated using these indices at days 4, 8, and 15.

Results: Comparison of PGA score, TEWL, and VAS score at baseline with those at days 4, 8, and 15 of treatment showed a significant improvement in both groups. Patients who applied mometasone furoate in MLE (74.8%) showed better results (p<0.05) than those who applied methylprednisolone aceponate (47.8%). The TEWL improvement ratio was higher in the mometasone furoate in MLE group than that in the methylprednisolone aceponate group, and VAS improvement was also better in the mometasone furoate in MLE group.

Conclusion: Mometasone furoate in MLE has a better therapeutic efficacy as well as less skin barrier impairment than methylprednisolone aceponate.

Keywords: Ceramide; Corticosteroid; Eczema; Multi-lammelar emulsion; Skin-barrier.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
The physician's global assessment of clinical response (PGA) improvement ratio at day 4, 8, 15. Comparison of the PGA improvement ratio between themometasone furoate in multi-lamella emulsion (MLE) group and the methylprednisolone group. A significant difference was observed in the PGA improvement ratio at all follow-up periods (p≤0.0001).
Fig. 2
Fig. 2
The trans-epidermal water loss (TEWL) improvement ratio. Comparison of the TEWL improvement ratio between the mometasone furorate in multi-lamella emulsion (MLE) group and the methylprednisolone group. A significant difference was observed in the TEWL improvement ratio at all follow-up periods (p≤0.0001).
Fig. 3
Fig. 3
The visual analog scale (VAS) improvement ratio. Comparison of the VAS improvement ratio between the mometasone furorate in multi-lamella emulsion (MLE) group and the methylprednisolone group. A significant difference was observed in the VAS improvement ratio at day 15 (p≤0.0001).
See this image and copyright information in PMC

References

    1. Lange K, Gysler A, Bader M, Kleuser B, Korting HC, Schäfer-Korting M. Prednicarbate versus conventional topical glucocorticoids: pharmacodynamic characterization in vitro. Pharm Res. 1997;14:1744–1749. - PubMed
    1. Lubach D, Rath J, Kietzmann M. Steroid-induced dermal thinning: discontinuous application of clobetasol-17-propionate ointment. Dermatology. 1992;185:44–48. - PubMed
    1. Leung DYM, Eichenfield LF, Boguniewicz M. Atopic dermatitis. In: Wolff K, Fitzpatrick TB, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, et al., editors. Fitzpatrick's dermatology in general medicine. 7th ed. New York: McGraw-Hill; 2008. pp. 146–158.
    1. Elias PM. Lipids and the epidermal permeability barrier. Arch Dermatol Res. 1981;270:95–117. - PubMed
    1. Elias PM. Epidermal lipids, membranes, and keratinization. Int J Dermatol. 1981;20:1–19. - PubMed

LinkOut - more resources