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Case Reports
. 2011 Sep;23(3):232-5.
doi: 10.1007/s11670-011-0232-y.

Oxaliplatin-induced lung injury with allergic reaction

Tetsuya Homma  1 , Masatsugu Kurokawa, Yoshitaka Yamamoto, Satoshi Matsukura, Koushi Ieki, Shintaro Suzuki, Miho Odaka, Shin Watanabe, Munehiro Yamaguchi, Mitsuru Adachi
Affiliations
Case Reports

Oxaliplatin-induced lung injury with allergic reaction

Tetsuya Homma et al. Chin J Cancer Res. 2011 Sep.

Abstract

A 79-year-old man was diagnosed as stage IV colon cancer and treated with a modified FOLFOX6 (mFOLFOX6) regimen. On the 12th cycle, we observed erythema and dyspnea. Radiographs showed ground grass opacities. Blood tests showed elevated levels of eosinophils and immunoglobulin E. We diagnosed this finding as response to drug allergy and administered high-dose methylprednisolone. The treatment was successful and he was discharged. The drug lymphocyte stimulating test against oxaliplatin was positive, indicating a type I and IV allergic reaction due to oxaliplatin. Regimens including oxaliplatin must be carefully monitored and frequent blood tests and chest radiographs are needed.

Keywords: Drug lymphocyte stimulating test; Drug-induced pneumonia; Immunoglobulin E; Oxaliplatin; mFOLFOX6.

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Figures

Figure 1
Figure 1
Image finding. Chest radiography (A) and CT (B) revealed bilateral ground grass opacities after administration of oxaliplatin. The images were compatible with that COP pattern.
See this image and copyright information in PMC

References

    1. André T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004; 350:2343-51 - PubMed
    1. Meyer L, Zuberbier T, Worm M, et al. Hypersensitivity reactions to oxaliplatin: cross-reactivity to carboplatin and the introduction of a desensitization schedule. J Clin Oncol 2002; 20:1146-7 - PubMed
    1. Makrilia N, Syrigou E, Kaklamanos I, et al. Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review. Met Based Drugs 2010; 2010:? - PMC - PubMed
    1. Costabel U, Teschler H, Guzman J.Bronchiolitis obliterans organizing pneumonia (BOOP): the cytological and immunocytological profile of bronchoalveolar lavage. Eur Respir J 1992; 5:791-7 - PubMed
    1. Rubbia-Brandt L, Audard V, Sartoretti P, et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Ann Oncol 2004; 15:460-6 - PubMed

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