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. 2013 Aug;29(8):1443-52.
doi: 10.1007/s11274-013-1307-3. Epub 2013 Mar 7.

Identification and characterization of antifungal active substances of Streptomyces hygroscopicus BS-112

Nan Zhang  1 , Zhen Song, Yuhua Xie, Ping Cui, Hongxia Jiang, Tao Yang, Ruicheng Ju, Yuhua Zhao, Jinyu Li, Xunli Liu
Affiliations

Identification and characterization of antifungal active substances of Streptomyces hygroscopicus BS-112

Nan Zhang et al. World J Microbiol Biotechnol. 2013 Aug.

Abstract

An antifungal Actinomyces BS-112 strain, with Aspergillus flavus as the target pathogen, was isolated from soil in the forest land of Mountain Tai. This strain showed a strong antagonistic activity against various mold fungi in food and feed. Strain BS-112 was identified as Streptomyces hygroscopicus based on its morphologic, cultural, physiological, biochemical characteristics, cell wall components and 16S rDNA sequence. Four active components were separated and purified from strain BS-112. These four antifungal components were identified as tetrins A and B and tetramycins A and B using spectroscopic analysis including mass spectrometry and nuclear magnetic resonance spectroscopy. Tetrins A and B and tetramycins A and B strongly inhibited the growth of A. flavus, A. alutaceus, A. niger, and A. fumigatus in vitro.

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