doi: 10.1248/cpb.38.698.
Studies on cytotoxic constituents in pericarps of Mallotus japonicus. IV
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- PMID: 2347013
- DOI: 10.1248/cpb.38.698
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Studies on cytotoxic constituents in pericarps of Mallotus japonicus. IV
Chem Pharm Bull (Tokyo).
1990 Mar.
Abstract
Two new phloroglucinol derivatives, isomallotolerin (1) and isomallotochromanol (2), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-methy l-6- methoxybenzyl)-phlorisobutyrophenone (1) and 6-acetyl-5,7-dihydroxy-8-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzy l)-2,2- dimethyl-3-hydroxychroman (2) from chemical and spectral data. Isomallotolerin and its acetate were found to be cytotoxic to KB cell line.
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