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Editorial
. 2013 Mar 15;12(6):865-6.
doi: 10.4161/cc.24217. Epub 2013 Mar 7.

The yin and yang of cyclin control by nutrients

Javier Jiménez, Andrew W Truman, Sandra Menoyo, Stephen J Kron, Josep Clotet
Editorial

The yin and yang of cyclin control by nutrients

Javier Jiménez et al. Cell Cycle. .
No abstract available

Keywords: Cln3; Pho85; Ssa1; cell cycle; nitrogen; phosphate; yeast.

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Figures

None
Figure 1. Nutrient signals converge on Cln3 via divergent activities of Pho85. Phosphate availability activates the PHO pathway, wherein the cyclin Pho80 activates the CDK Pho85 to directly phosphorylate Cln3 on the borders of the PEST degron, thereby protecting Cln3 from ubiquitin-proteasomal degradation. The resulting Cln3 stabilization permits Cdk1-Cln3 activity to accumulate and promote G1/S progression. By contrast, nitrogen starvation or sensing of mating pheromone induce cyclins Clg1 or Pcl2 to activate Pho85 to phosphorylate the chaperone Ssa1. Cln3 binding and PEST phosphorylation induce Cln3 degradation. Thus, nitrogen or phosphate starvation similarly block cell cycle progression via regulation of opposing functions of Pho85.
See this image and copyright information in PMC

Comment on

  • Menoyo S, Ricco N, Bru S, Hernández-Ortega S, Escoté X, Aldea M, et al. Phosphate-activated CDK stabilizes G1 cyclin to trigger cell cycle entry. Mol Cell Biol. 2013 doi: 10.1128/MCB.01556-12. doi: 10.1128/MCB.01556-12
  • Truman AW, Kristjansdottir K, Wolfgeher D, Hasin N, Polier S, Zhang H, et al. CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression. Cell. 2012;151:1308–18. doi: 10.1016/j.cell.2012.10.051. doi: 10.1016/j.cell.2012.10.051

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    1. Menoyo S, Ricco N, Bru S, Hernández-Ortega S, Escoté X, Aldea M, et al. Phosphate-activated CDK stabilizes G1 cyclin to trigger cell cycle entry. Mol Cell Biol. 2013 doi: 10.1128/MCB.01556-12. - DOI - PMC - PubMed
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