Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep;32(9):978-80.
doi: 10.1097/INF.0b013e31829044a8.

Raltegravir in vitro effect on bilirubin binding

Diana F Clarke  1 , Ronald J Wong, Larissa Wenning, David K Stevenson, Mark Mirochnick
Affiliations

Raltegravir in vitro effect on bilirubin binding

Diana F Clarke et al. Pediatr Infect Dis J. 2013 Sep.

Abstract

Drugs that displace bilirubin from albumin may increase the risk of kernicterus in neonates. We evaluated the effect of raltegravir on bilirubin-albumin binding in pooled neonatal serum using the peroxidase method. Raltegravir had minimal effect on bilirubin-albumin binding at concentrations of 5 and 10 µM, caused a small but statistically significant increase in unbound bilirubin at 100 µM and caused potentially harmful increases at 500 and 1000 µM. Our data suggest that the effect of raltegravir on neonatal bilirubin binding is unlikely to be clinically significant at typical peak concentrations reached with usual dosing.

PubMed Disclaimer

References

    1. Mirochnick M, Best B, Clarke D. Antiretroviral Pharmacology: Special Issues Regarding Pregnant Women and Neonates. Clinics in Perinatology. 2010:37. - PubMed
    1. Andersen DH, Blanc WA, Crozier DN, Silverman WA. A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens. Pediatrics. 1956;18(4):614–25. - PubMed
    1. Harris RC, Lucey JF, Maclean JR. Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma. Pediatrics. 1958;21(6):875–84. - PubMed
    1. Jacobsen J, Wennberg RP. Determination of unbound bilirubin in the serum of newborns. Clin Chem. 1974;20(7):783. - PubMed
    1. Ahlfors CE. Effect of ibuprofen on bilirubin-albumin binding. J Pediatr. 2004;144(3):386–8. - PubMed

Publication types