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Comment
. 2013 Mar 7;12(3):266-8.
doi: 10.1016/j.stem.2013.02.004.

An inflammatory situation: SOX2 and STAT3 cooperate in squamous cell carcinoma initiation

Adam J Bass  1 , Timothy C Wang
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An inflammatory situation: SOX2 and STAT3 cooperate in squamous cell carcinoma initiation

Adam J Bass et al. Cell Stem Cell. .
Free article

Abstract

Although SOX2 has been identified as a squamous cell carcinoma oncogene, mechanisms of SOX2-induce oncogenesis have remained elusive. In this issue of Cell Stem Cell, Li et al. (2013) show that SOX2 synergizes with inflammation-induced STAT3 activation to transform basal progenitors and initiate squamous cell carcinoma.

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