Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Mar 7;12(3):269-70.
doi: 10.1016/j.stem.2013.02.006.

BCL-2 inhibition: stemming the tide of myeloid malignancies

Leah J Hogdal  1 , Anthony Letai
Affiliations
Comment

BCL-2 inhibition: stemming the tide of myeloid malignancies

Leah J Hogdal et al. Cell Stem Cell. .

Abstract

Leukemia stem cells (LSCs) are likely to be the source for both therapeutic resistance and relapse in myeloid malignancies. As reported in this issue of Cell Stem Cell, Lagadinou et al. (2013) and Goff et al. (2013) support selective targeting of LSCs by small molecule antagonists of anti-apoptotic BCL-2 family proteins.

PubMed Disclaimer

Comment on

References

    1. Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong Sa, Letai A. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood. 2008;111:2300–2309. - PMC - PubMed
    1. Goff DJ, Recart AC, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, et al. A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition. Cell Stem Cell 2013 - PMC - PubMed
    1. Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, Deng X, Zhai D, Shi YX, Sneed T, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006;10:375–388. - PubMed
    1. Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O'Dwyer KM, et al. BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells. Cell Stem Cell 2013 - PMC - PubMed
    1. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Coretes J, Minden M, Paterson B, Caligiuri M, Dick J. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:345–648. - PubMed

MeSH terms

Substances