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. 2013 Mar 2;381(9868):774-5.
doi: 10.1016/S0140-6736(12)61815-7.

Sepsis definitions: time for change

Jean-Louis Vincent  1 , Steven M Opal, John C Marshall, Kevin J Tracey
Affiliations

Sepsis definitions: time for change

Jean-Louis Vincent et al. Lancet. .
No abstract available

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Conflict of interest statement

Conflicts of interest: We declare that we have no conflicts of interest.

Figures

Figure
Figure. Infectious and non-infectious stimuli that activate innate immunity and cytokine release and can cause sepsis
LPS=lipopolysaccharide. HMGB1=high mobility group box 1. mDNA=mitochondrial DNA. TLR=toll-like receptor. NOD=nucleotide-binding oligomerisation domain protein. NLR=NOD-like receptor. RIG=retinoic-acid-inducible gene. TNF=tumour necrosis factor.
See this image and copyright information in PMC

Comment in

  • Sepsis definitions.
    Lucas S. Lucas S. Lancet. 2013 Jun 29;381(9885):2249. doi: 10.1016/S0140-6736(13)61474-9. Lancet. 2013. PMID: 23809552 No abstract available.
  • Sepsis definitions.
    Cascio A, Iaria C. Cascio A, et al. Lancet. 2013 Jun 29;381(9885):2249. doi: 10.1016/S0140-6736(13)61473-7. Lancet. 2013. PMID: 23809553 No abstract available.
  • Sepsis definitions.
    Inoue K, Takano H. Inoue K, et al. Lancet. 2013 Jun 29;381(9885):2249-50. doi: 10.1016/S0140-6736(13)61475-0. Lancet. 2013. PMID: 23809554 No abstract available.
  • Sepsis definitions - Authors' reply.
    Vincent JL, Opal SM, Marshall JC, Tracey KJ. Vincent JL, et al. Lancet. 2013 Jun 29;381(9885):2250. doi: 10.1016/S0140-6736(13)61476-2. Lancet. 2013. PMID: 23809556 No abstract available.

References

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    1. Sprung CL, Sakr Y, Vincent JL, et al. An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study. Intensive Care Med. 2006;32:421–27. - PubMed
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    1. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250–56. - PubMed
    1. Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol. 2011;29:139–62. - PMC - PubMed

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